金沙娱城乐377

金沙娱城乐377

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LH026

LH026是有抗炎作用的多肽化合物, 利用AKNANO®专利技术实现了大分子多肽药物通过黏膜途径给药,可于皮肤、鼻黏膜喷涂,使用方便、无激素类副作用、起效迅速,针对过敏性鼻炎、银屑病具有很好的治疗效果。


LH026药理作用机制直接针对炎症通路,具有双重抗炎作用。一方面可通过抑制PRCP进而抑制α-MSH的降解,另一方面通过抑制IL-1β和TNF-α诱导的NF-κB激活而发挥抗炎作用。


体内药效研究:
1. 过敏性鼻炎

 










1. LH026缓解过敏性鼻炎小鼠的鼻部瘙痒症状

 



















2. LH026抑制鼻腔嗜酸性粒细胞浸润

 










3. LH026降低鼻黏膜IL-1RI表达。

 

  数据来源:《Rsc Advances, 2014 , 4 (89) :48741-48749

2. 银屑病




















  图4. LH025能显著改善银屑病皮损皮肤的厚度及完整性 (HE染色)

 

 

AKNANO®技术能在生物黏膜表面留下稳定脂质层活性物质,使活性物质快速发挥作用,具有以下特点:

脂质和活性物质通过直接沉积,快速和高效的跟皮肤屏障发生理化作用。

该技术中使用的脂质跟皮肤细胞中的脂质非常相似,能跟皮肤快速的相适应,提高给药效率。

用药部位的活性物质均匀分布,形成一个统一的脂质层,给药剂量准确。

无防腐剂和刺激剂,无油脂和黏性,用药部位无不适感觉;使用简单、快速、方便;相对于其他局部制剂,患者使用的顺应性好。

该脂质技术有专利保护,提高了仿制技术壁垒,可延长产品生命周期。

 

金沙娱城总站3777获得lipidor公司AKNANO®专利的独占许可。





Product opportunities in topical treatment

Lipidor offers unique lipid based formulation opportunities across dermatology, wound and skin care markets. 

The technology, AKVANO®, represents a new sprayable dosage form for effective topical delivery of drugs and skin care treatment. AKVANO is designed for local treatment, not for systemic delivery.

The versatility of AKVANO technology enables the incorporation of structurally different active ingredients.

More than 80 active ingredients have so far been successfully incorporated into AKVANO, of which more than 50 APIs.



Lipidor offers the AKVANO technology to pharmaceutical companies interested

in cooperation and licensing arrangements for:

  • Formulation of NCE´s for topical treatment
  • Reformulation of existing topical products




LIPID LAYER & STRATUM CORNEUM

AKVANO formulations instantly form a thin lipid layer in which the active substance is evenly distributed,enabling quicker, direct penetration into the stratum corneum.




Compounds successfully incorporated into AKVANO
More than 50 pharmaceutical compounds have been successfully incorporated in AKVANO to date (evaluated at accelerated conditions and found to be chemically stable), for dermatology indications such as psoriasis, atopic dermatitis, eczema, dry skin, acne and pain, including: 

  • NCEs
  • Calcipotriol + corticosteroids (e.g. betamethasone dipropionate)
  • Fusidic acid, sodium salt
  • Hydrocortisone, betamethasone valerate, betamethasone dipropionate, mometasone furoate
  • Diclofenac sodium, naproxen, ibuprofen, ketoprofen
  • Econazole nitrate, terbinafine hydrochloride
  • Minoxidil
  • Lidocaine, prilocaine/lidocaine, benzocaine
  • Dexpanthenol, niacinamide, salicylic acid
  • Tacrolimus  
  • More

AKVANO sprayable formulations offer advantages in key areas:

  • Lipid-based approach enables skin barrier reinforcement
  • Direct deposition of lipids on the skin
  • Non-touch functionality
  • Efficient development and manufacturing
  • The AKVANO technology is protected by granted patents or patent applications



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